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Article

Gene of the month: <i>BECN1</i>

7 May 2014

Abstract excerpt

The BECN1 gene encodes the Beclin-1 protein, which is a well-established regulator of the autophagic pathway. It is a mammalian orthologue of the ATG6 gene in yeast and was one of the first identified mammalian autophagy-associated genes. Beclin-1 interacts with a number of binding partners in the cell which can lead to either activation (eg, via PI3KC3/Vps34, Ambra 1, UV radiation resistance-associated gene) or...

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PMID: 24811486
DOI: 10.1136/jclinpath-2014-202356

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