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Article

The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function.

Kidney international - 1 Jun 2014

Faria Diana, Rock Jason R, Romao Ana M, Schweda Frank, Bandulik Sascha, Witzgall Ralph, Schlatter Eberhard, Heitzmann Dirk, Pavenstädt Hermann, Herrmann Edwin, Kunzelmann Karl, Schreiber Rainer

Abstract excerpt

The role of calcium-activated chloride channels for renal function is unknown. By immunohistochemistry we demonstrate dominant expression of the recently identified calcium-activated chloride channels, Anoctamin 1 (Ano1, TMEM16A) in human and mouse proximal tubular epithelial (PTE) cells, with some expression in podocytes and other tubular segments. Ano1-null mice had proteinuria and numerous large reabsorption...

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Identifiers

PMID: 24476694
DOI: 10.1038/ki.2013.535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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