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Article

Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria.

American journal of physiology. Renal physiology - 1 Dec 2018

Schenk Laura K, Buchholz Bjoern, Henke Sebastian F, Michgehl Ulf, Daniel Christoph, Amann Kerstin, Kunzelmann Karl, Pavenstädt Hermann

Abstract excerpt

TMEM16A is a transmembrane protein from a conserved family of calcium-activated proteins that is highly expressed in the kidney. TMEM16A confers calcium-activated chloride channel activity, which is of importance for various cellular functions in secretory epithelia and involved in secretion-dependent renal cyst growth. However, its specific function in renal physiology has remained elusive so far. Therefore, we...

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PMID: 30156115
DOI: 10.1152/ajprenal.00638.2017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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