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Article

Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology.

Circulation research - 30 Mar 2012

Yu Kuai, Duran Charity, Qu Zhiqiang, Cui Yuan-Yuan, Hartzell H Criss

Abstract excerpt

RATIONALE: Ca2+ -activated Cl channels play pivotal roles in the cardiovascular system. They regulate vascular smooth muscle tone and participate in cardiac action potential repolarization in some species. Ca2+ -activated Cl channels were recently discovered to be encoded by members of the anoctamin (Ano, also called Tmem16) superfamily, but the mechanisms of Ano1 gating by Ca2+ remain enigmatic. OBJECTIVE: The...

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Identifiers

PMID: 22394518
DOI: 10.1161/CIRCRESAHA.112.264440
PMCID: PMC3558997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology.PMID 22394518Read ↗

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