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Article

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels.

The Journal of general physiology - 1 Oct 2013

Vocke Kerstin, Dauner Kristin, Hahn Anne, Ulbrich Anne, Broecker Jana, Keller Sandro, Frings Stephan, Möhrlen Frank

Abstract excerpt

Calcium-dependent chloride channels serve critical functions in diverse biological systems. Driven by cellular calcium signals, the channels codetermine excitatory processes and promote solute transport. The anoctamin (ANO) family of membrane proteins encodes three calcium-activated chloride channels, named ANO 1 (also TMEM16A), ANO 2 (also TMEM16B), and ANO 6 (also TMEM16F). Here we examined how ANO 1 and ANO 2...

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Identifiers

PMID: 24081981
DOI: 10.1085/jgp.201311015
PMCID: PMC3787769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels.PMID 24081981Read ↗

Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology.Semantic proximity Read ↗

Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium.Semantic proximity Read ↗

Acidic amino acids in the first intracellular loop contribute to voltage- and calcium- dependent gating of anoctamin1/TMEM16A.Semantic proximity Read ↗

Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?Semantic proximity Read ↗

Structure and function of TMEM16 proteins (anoctamins).Semantic proximity Read ↗

The voltage dependence of the TMEM16B/anoctamin2 calcium-activated chloride channel is modified by mutations in the first putative intracellular loop.Semantic proximity Read ↗

Ca2+ Sensitivity of Anoctamin 6/TMEM16F Is Regulated by the Putative Ca2+-Binding Reservoir at the N-Terminal Domain.Semantic proximity Read ↗

Voltage-Dependent Protonation of the Calcium Pocket Enable Activation of the Calcium-Activated Chloride Channel Anoctamin-1 (TMEM16A).Semantic proximity Read ↗

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.Semantic proximity Read ↗

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Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicingSemantic proximity Read ↗

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