Article
Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 2011
Paulais Marc, Bloch-Faure May, Picard Nicolas, Jacques Thibaut, Ramakrishnan Suresh Krishna, Keck Mathilde, Sohet Fabien, Eladari Dominique, Houillier Pascal, Lourdel Stéphane, Teulon Jacques, Tucker Stephen J
Abstract excerpt
The heteromeric inwardly rectifying Kir4.1/Kir5.1 K(+) channel underlies the basolateral K(+) conductance in the distal nephron and is extremely sensitive to inhibition by intracellular pH. The functional importance of Kir4.1/Kir5.1 in renal ion transport has recently been highlighted by mutations in the human Kir4.1 gene (KCNJ10) that result in seizures, sensorineural deafness, ataxia, mental retardation, and...
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