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Article

Protons inhibit anoctamin 1 by competing with calcium.

Cell calcium - 1 Nov 2015

Chun Hyeyeon, Cho Hawon, Choi Jimi, Lee Jesun, Kim Sung Min, Kim Hyungsup, Oh Uhtaek

Abstract excerpt

Cl(-) efflux through Ca(2+)-activated Cl(-) channels (CaCCs) in secretory epithelial cells plays a key role in the regulation of fluid secretion. The fluid and electrolyte secretion is closely related to intracellular pH. CaCCs have been known to be inhibited by intracellular acid. However, the molecular mechanism for the inhibition remains unknown. Anoctamin 1 (ANO1) is a Ca(2+)-activated Cl(-) channel that...

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Source

Identifiers

PMID: 26183761
DOI: 10.1016/j.ceca.2015.06.011

Genes

ANO1
ANO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protons inhibit anoctamin 1 by competing with calcium.PMID 26183761Read ↗

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