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Article

Impact of measurement error on testing genetic association with quantitative traits.

PloS one - 1 Jan 2014

Liao Jiemin, Li Xiang, Wong Tien-Yin, Wang Jie Jin, Khor Chiea Chuen, Tai E Shyong, Aung Tin, Teo Yik-Ying, Cheng Ching-Yu

Abstract excerpt

Measurement error of a phenotypic trait reduces the power to detect genetic associations. We examined the impact of sample size, allele frequency and effect size in presence of measurement error for quantitative traits. The statistical power to detect genetic association with phenotype mean and variability was investigated analytically. The non-centrality parameter for a non-central F distribution was derived and...

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Identifiers

PMID: 24475218
DOI: 10.1371/journal.pone.0087044
PMCID: PMC3901720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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