Article
The effect of measurement error of phenotypes on genome wide association studies.
BMC genomics - 12 May 2011
Barendse William
Abstract excerpt
BACKGROUND: There is an unspoken assumption that imprecision of measurement of phenotypes will not have large systematic effects on the location of significant associations in a genome wide association study (GWAS). In this report, the effects of two independent measurements of the same trait, subcutaneous fat thickness, were examined in GWAS of 940 individuals. RESULTS: The trait values obtained by two...
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