How allele frequency and study design affect association test statistics with misrepresentation errors.

Abstract excerpt

We evaluate the effect of genotyping errors on the type-I error of a general association test based on genotypes, showing that, in the presence of errors in the case and control samples, the test statistic asymptotically follows a scaled non-central $\chi ^2$ distribution. We give explicit formulae for the scaling factor and non-centrality parameter for the symmetric allele-based genotyping error model and for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Frequency
• Share to Genotype
• Share to Genotyping Techniques