Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of phenotype variation on detection of linkage in the COGA data.

Genetic epidemiology - 1 Jan 1999

Birznieks G, Ghosh S, Watanabe R M, Mitchell B D

Abstract excerpt

Error in phenotypic measurement can significantly compromise ability to detect linkage. We assessed the impact of introducing phenotypic measurement error on our ability to detect a quantitative trait locus in the Collaborative Study on the Genetics of Alcoholism (COGA) data. The impact of introducing three different types of errors was evaluated: 1) errors generated by sampling from a normal distribution; 2)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Genetic Linkage
Share to Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome

Share to Lod Score

Share to Quantitative Trait, Heritable

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 10597413
DOI: 10.1002/gepi.1370170711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of phenotype variation on detection of linkage in the COGA data.PMID 10597413Read ↗

Genotyping errors, pedigree errors, and missing data.Semantic proximity Read ↗

Genotyping errors and their impact on genetic analysis.Semantic proximity Read ↗

Comparison of single-nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3.Semantic proximity Read ↗

Linkage mapping methods applied to the COGA data set: presentation Group 4 of Genetic Analysis Workshop 14.Semantic proximity Read ↗

Dissection of heterogeneous phenotypes for quantitative trait mapping.Semantic proximity Read ↗

Association and linkage analysis of ICD-10 diagnosis for alcoholism.Semantic proximity Read ↗

The impact of genotyping error on family-based analysis of quantitative traits.Semantic proximity Read ↗

The effect of measurement error of phenotypes on genome wide association studies.Semantic proximity Read ↗

Assessment and management of single nucleotide polymorphism genotype errors in genetic association analysis.Semantic proximity Read ↗

Molecular and statistical approaches to the detection and correction of errors in genotype databases.Semantic proximity Read ↗

Linkage analysis of alcohol dependence using both affected and discordant sib pairs.Semantic proximity Read ↗

Effect of genotyping error in model-free linkage analysis using microsatellite or single-nucleotide polymorphism marker maps.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.