Article
Frequent POLE1 p.S297F mutation in Chinese patients with ovarian endometrioid carcinoma.
Mutation research - 1 Mar 2014
Zou Yang, Liu Fa-Ying, Liu Huai, Wang Feng, Li Wei, Huang Mei-Zhen, Huang Yan, Yuan Xiao-Qun, Xu Xiao-Yun, Huang Ou-Ping, He Ming
Abstract excerpt
The catalytic subunit of DNA polymerase epsilon (POLE1) functions primarily in nuclear DNA replication and repair. Recently, POLE1 mutations were detected frequently in colorectal and endometrial carcinomas while with lower frequency in several other types of cancer, and the p.P286R and p.V411L mutations were the potential mutation hotspots in human cancers. Nevertheless, the mutation frequency of POLE1 in...
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