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Article

An exploratory analysis of driver gene alterations and their potential prognostic relevance in endometrial cancer with POLE exonuclease domain mutations.

Gynecologic oncology - 1 Aug 2025

Wei Tsai-Yin, Wu Chao-Chih, Hsu Yun-Ting, Lin Wen-Hsuan, Tsai Li-Chu, Shieh Dar-Bin, Chang Chih-Long

Abstract excerpt

OBJECTIVE: Endometrial cancer represents a significant gynecologic malignancy affecting women globally, including Taiwan. This study aimed to analyze mutation patterns in endometrial cancer genes related to POLE exonuclease domain mutations and their association with patient prognosis. METHODS: We analyzed 100 endometrial cancer tissue samples from patients at MacKay Memorial Hospital (February 2014-February...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40516204
DOI: 10.1016/j.ygyno.2025.06.006

Genes

POLE
TP53
CLC
CTNNB1
KRAS
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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An exploratory analysis of driver gene alterations and their potential prognostic relevance in endometrial cancer with POLE exonuclease domain mutations.PMID 40516204Read ↗

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The clinicopathology and survival characteristics of patients with POLE proofreading mutations in endometrial carcinoma: A systematic review and meta-analysis.Semantic proximity Read ↗

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A novel somatic mutation in POLE exonuclease domain associated with ultra-mutational signature and MMR deficiency in endometrial cancer: a case reportSemantic proximity Read ↗

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