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Article

Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer

12 Oct 2022

Abstract excerpt

Objective This study was aimed to profile hotspot exonuclease domain mutations (EDMs) of the DNA polymerase ϵ gene ( POLE ) in endometrial cancer (EC) and to investigate the effects of EDMs on tumor cell behavior and catalytic activities of Polϵ. Methods POLE sequencing was performed in tumor tissue samples from patients with EC to identify hotspot EDMs. Bioinformatics tools were used to select the potential...

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Identifiers

PMID: 36313640
DOI: 10.3389/fonc.2022.1018034

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