Investigation of the conserved glutamate immediately following the DEAD box in eukaryotic translation initiation factor 4AI.

doi:10.1139/bcb-2013-0076

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Article

Investigation of the conserved glutamate immediately following the DEAD box in eukaryotic translation initiation factor 4AI.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Feb 2014

Patel Krishnaben, Shah Grishma K, Kommaraju Sai Shilpa, Low Woon-Kai

Abstract excerpt

The DExD-box family (DEAD-box) of proteins was surveyed for eukaryotic translation initiation factor 4A-specific sequences surrounding the DEAD box. An eIF4A-unique glutamate residue (E186 in eIF4AI) was identified immediately following the D-E-A-D sequence in eIF4AI, II, and III that was found to be conserved from yeast to Man. Mutation to a selection of alternative amino acids was performed within recombinant...

Topics

Adenosine Triphosphatases
Eukaryotic Initiation Factor-4A
Fungal Proteins
Glutamic Acid
Humans
Mutation
Protein Binding

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Open in PubMed

Identifiers

PMID: 24471916
DOI: 10.1139/bcb-2013-0076

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