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Article

Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex.

Genes & development - 15 May 2011

Alexandrov Andrei, Colognori David, Steitz Joan A

Abstract excerpt

Despite the lack of an exon junction complex (EJC), Saccharomyces cerevisiae contains Fal1p, a DEAD-box helicase highly homologous to eIF4AIII. We show that yeast Fal1p is functionally orthologous to human eIF4AIII, since expression of human eIF4AIII complements both the lethal phenotype and the 18S rRNA biogenesis defect of fal1Δ(null) yeast. We further show that yeast Fal1p interacts genetically with an...

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Share to DEAD-box RNA Helicases
Share to Eukaryotic Initiation Factor-4G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Genetic Complementation Test

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Share to RNA, Ribosomal, 18S

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Source

Open in PubMed Open full text

Identifiers

PMID: 21576267
DOI: 10.1101/gad.2045411
PMCID: PMC3093123

Genes

NOM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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