Article
Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.
Science (New York, N.Y.) - 29 Sept 2006
Andersen Christian B F, Ballut Lionel, Johansen Jesper S, Chamieh Hala, Nielsen Klaus H, Oliveira Cristiano L P, Pedersen Jan Skov, Séraphin Bertrand, Le Hir Hervé, Andersen Gregers Rom
Abstract excerpt
In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence messenger RNA function. Here, we present the crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase (ATPase) eukaryotic initiation factor 4AIII...
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