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Article

Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay.

RNA (New York, N.Y.) - 1 Mar 2006

Shibuya Toshiharu, Tange Thomas Ø, Stroupe M Elizabeth, Moore Melissa J

Abstract excerpt

The exon junction complex (EJC) is deposited on mRNAs by the process of pre-mRNA splicing and is a key effector of downstream mRNA metabolism. We previously demonstrated that human eIF4AIII, which is essential for nonsense-mediated mRNA decay (NMD), constitutes at least part of the RNA-binding platform anchoring other EJC components to the spliced mRNA. To determine the regions of eIF4AIII that are functionally...

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Identifiers

PMID: 16495234
DOI: 10.1261/rna.2190706
PMCID: PMC1383576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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