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Article

Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.

Journal of the American Heart Association - 27 Jan 2014

Tie Guodong, Messina Katharine E, Yan Jinglian, Messina Julia A, Messina Louis M

Abstract excerpt

BACKGROUND: Clinical studies suggest that hypercholesterolemia may cause ageing in hematopoietic stem cells (HSCs) because ageing-associated alterations were found in peripheral blood cells and their bone marrow residing precursors in patients with advanced atherosclerosis. We hypothesized that h...

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Identifiers

PMID: 24470519
DOI: 10.1161/JAHA.113.000241
PMCID: PMC3959695

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24470519-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.PMID 24470519Read ↗

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