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Article

Polymerase I and transcript release factor transgenic mice show impaired function of hematopoietic stem cells.

Aging - 21 Oct 2020

Bai Lin, Lyu Ying, Shi Guiying, Li Keya, Huang Yiying, Ma Yuanwu, Cong Yu-Sheng, Zhang Lianfeng, Qin Chuan

Abstract excerpt

The age-dependent decline in stem cell function plays a critical role in aging, although the molecular mechanisms remain unclear. PTRF/Cavin-1 is an essential component in the biogenesis and function of caveolae, which regulates cell proliferation, endocytosis, signal transduction and senescence. This study aimed to analyze the role of PTRF in hematopoietic stem cells (HSCs) senescence using PTRF transgenic mice....

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Identifiers

PMID: 33087586
DOI: 10.18632/aging.103729
PMCID: PMC7655181

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