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Article

Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway.

Scientific reports - 27 Feb 2020

Tie Guodong, Yan Jinglian, Khair Lyne, Tutto Amanda, Messina Louis M

Abstract excerpt

Hypercholesterolemia accelerates the phenotypes of aging in hematopoietic stem cells (HSCs). As yet, little is known about the underlying mechanism. We found that hypercholesterolemia downregulates Ten eleven translocation 1 (Tet1) in HSCs. The total HSC population was increased, while the long-term (LT) population, side population and reconstitution capacity of HSCs were significantly decreased in Tet1-/- mice....

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Identifiers

PMID: 32107419
DOI: 10.1038/s41598-020-60403-w
PMCID: PMC7046636

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