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Article

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche.

Cells - 21 Jul 2021

Yang Daozheng, de Haan Gerald

Abstract excerpt

Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages. The functioning of aged HSCs is impaired, including a declined repopulation capacity and myeloid and platelet-restricted differentiation. Both cell-intrinsic and microenvironmental extrinsic factors contribute to HSC aging. Recent studies highlight the emerging role of inflammation in contributing to HSC aging. In this...

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Identifiers

PMID: 34440618
DOI: 10.3390/cells10081849
PMCID: PMC8391820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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