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Article

The ageing haematopoietic stem cell compartment.

Nature reviews. Immunology - 1 May 2013

Geiger Hartmut, de Haan Gerald, Florian M Carolina

Abstract excerpt

Stem cell ageing underlies the ageing of tissues, especially those with a high cellular turnover. There is growing evidence that the ageing of the immune system is initiated at the very top of the haematopoietic hierarchy and that the ageing of haematopoietic stem cells (HSCs) directly contributes to changes in the immune system, referred to as immunosenescence. In this Review, we summarize the phenotypes of...

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PMID: 23584423
DOI: 10.1038/nri3433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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