Article

Hypercholesterolaemia promotes epigenetic memory in hematopoietic stem cells that persists after lipid lowering and causes systemic immunometabolic dysfunction mediated by macrophage metabolic reprogramming

2025-09-18

Abstract excerpt

In patients with atherosclerotic cardiovascular disease (ASCVD) lowering LDL cholesterol (LDL-C) reduces the risk of adverse cardiovascular events. However, these patients remain at continued risk of adverse cardiovascular events despite achieving optimal LDL-C lowering. We hypothesised that this ‘residual risk’ is mediated by epigenetic programming of haematopoietic stem cells (HSC) which persists after cholester...

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Literature Corpus work: eb1add9b-a30f-5535-9f73-16647db778c4
DOI: 10.1101/2025.09.15.676283

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Hypercholesterolaemia promotes epigenetic memory in hematopoietic stem cells that persists after lipid lowering and causes systemic immunometabolic dysfunction mediated by macrophage metabolic reprogrammingDOI 10.1101/2025.09.15.676283Read

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