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Article

Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence.

Journal of cell science - 1 May 2007

Zhang Xiaoling, Sejas Daniel P, Qiu Yuhui, Williams David A, Pang Qishen

Abstract excerpt

The proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) inhibits hematopoietic stem cell (HSC) expansion, interferes with HSC self-renewal and compromises the ability of HSC to reconstitute hematopoiesis. We have investigated mechanisms by which TNFalpha suppresses hematopoiesis using the genomic instability syndrome Fanconi anemia mouse model deficient for the complementation-group-C gene (Fancc)....

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Identifiers

PMID: 17405815
DOI: 10.1242/jcs.003152
PMCID: PMC2857731

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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