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Article

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells

7 Jul 2011

Abstract excerpt

Stem cells of highly regenerative organs including blood are susceptible to endogenous DNA damage caused by both intrinsic and extrinsic stress. Response mechanisms to such stress equipped in hematopoietic stem cells (HSCs) are crucial in sustaining hematopoietic homeostasis but remain largely unknown. In this study, we demonstrate that serial transplantation of human HSCs into immunodeficient mice triggers...

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Identifiers

PMID: 21734240
DOI: 10.1182/blood-2011-01-330050

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