Article
Mutations in the Pseudomonas aeruginosa needle protein gene pscF confer resistance to phenoxyacetamide inhibitors of the type III secretion system.
Antimicrobial agents and chemotherapy - 1 Jan 2014
Bowlin Nicholas O, Williams John D, Knoten Claire A, Torhan Matthew C, Tashjian Tommy F, Li Bing, Aiello Daniel, Mecsas Joan, Hauser Alan R, Peet Norton P, Bowlin Terry L, Moir Donald T
Abstract excerpt
The type III secretion system (T3SS) is a clinically important virulence mechanism in Pseudomonas aeruginosa that secretes and translocates effector toxins into host cells, impeding the host's rapid innate immune response to infection. Inhibitors of T3SS may be useful as prophylactic or adjunctive therapeutic agents to augment the activity of antibiotics in P. aeruginosa infections, such as pneumonia and...
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