Toward Understanding the Outer Membrane Uptake of Small Molecules by Pseudomonas aeruginosa

Abstract excerpt

Because small molecules enter Gram-negative bacteria via outer membrane (OM) channels, understanding OM transport is essential for the rational design of improved and new antibiotics. In the human pathogen Pseudomonas aeruginosa, most small molecules are taken up by outer membrane carboxylate channel (Occ) proteins, which can be divided into two distinct subfamilies, OccD and OccK. Here we characterize substrate...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antibiotic Resistance in Bacteria
• Share to Bacterial Genetics and Biotechnology
• Share to Clostridium difficile and Clostridium perfringens research