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Article

Global reprogramming of virulence and antibiotic resistance in Pseudomonas aeruginosa by a single nucleotide polymorphism in elongation factor, fusA1.

The Journal of biological chemistry - 27 Nov 2020

Maunders Eve A, Triniman Rory C, Western Joshua, Rahman Taufiq, Welch Martin

Abstract excerpt

Clinical isolates of the opportunistic pathogen Pseudomonas aeruginosa from patients with cystic fibrosis (CF) frequently contain mutations in the gene encoding an elongation factor, FusA1. Recent work has shown that fusA1 mutants often display elevated aminoglycoside resistance due to increased expression of the efflux pump, MexXY. However, we wondered whether these mutants might also be affected in other...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32943550
DOI: 10.1074/jbc.RA119.012102
PMCID: PMC7705318

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