Article
Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.
PLoS genetics - 29 Feb 2008
Arnoldo Anthony, Curak Jasna, Kittanakom Saranya, Chevelev Igor, Lee Vincent T, Sahebol-Amri Mehdi, Koscik Becky, Ljuma Lana, Roy Peter J, Bedalov Antonio, Giaever Guri, Nislow Corey, Merrill A Rod, Merrill Rod A, Lory Stephen, Stagljar Igor
Abstract excerpt
Pseudomonas aeruginosa is an opportunistic human pathogen that is a key factor in the mortality of cystic fibrosis patients, and infection represents an increased threat for human health worldwide. Because resistance of Pseudomonas aeruginosa to antibiotics is increasing, new inhibitors of pharmacologically validated targets of this bacterium are needed. Here we demonstrate that a cell-based yeast phenotypic...
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