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Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs<i>Pseudomonas aeruginosa</i>Pathogenicity and Inflammasome Activation

13 Jul 2016

Abstract excerpt

With the rise of multidrug resistance, Pseudomonas aeruginosa infections require alternative therapeutics. The injectisome (iT3SS) and flagellar (fT3SS) type III secretion systems are 2 virulence factors associated with poor clinical outcomes. iT3SS translocates toxins, rod, needle, or regulator proteins, and flagellin into the host cell cytoplasm and causes cytotoxicity and NLRC4-dependent inflammasome...

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PMID: 27412581
DOI: 10.1093/infdis/jiw295

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