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Loss of the Ferripyochelin Receptor FptA Drives Reduced Cefiderocol Susceptibility and Impairs Fitness in <i>Pseudomonas aeruginosa</i> PA14

2025-09-16

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic human pathogen and a frequent cause of multidrug-resistant infections. This organism continues to evade antimicrobial therapy despite the clinical introduction of new anti-pseudomonal antibiotics over the past several years. One of these agents is cefiderocol (FDC), a novel siderophore-cephalosporin conjugate antibiotic that was designed to overcome both intrinsic and acq...

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Literature Corpus work
b173525f-56ad-53f0-85e0-bff4ac8e3668
DOI
10.1101/2025.09.16.676464
Open publication

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Loss of the Ferripyochelin Receptor FptA Drives Reduced Cefiderocol Susceptibility and Impairs Fitness in <i>Pseudomonas aeruginosa</i> PA14DOI 10.1101/2025.09.16.676464
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