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Article

A Structure-Function-Inhibition Analysis of the Pseudomonas aeruginosa Type III Secretion Needle Protein PscF.

Journal of bacteriology - 25 Aug 2020

Moir Donald T, Bowlin Nicholas O, Berube Bryan J, Yabut Jaden, Mills Debra M, Nguyen Giang T, Aron Zachary D, Williams John D, Mecsas Joan, Hauser Alan R, Bowlin Terry L

Abstract excerpt

The Pseudomonas aeruginosa type III secretion system (T3SS) needle comprised of multiple PscF subunits is essential for the translocation of effector toxins into human cells, facilitating the establishment and dissemination of infection. Mutations in the pscF gene provide resistance to the phenoxyacetamide (PhA) series of T3SS inhibitory chemical probes. To better understand PscF functions and interactions with...

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Identifiers

PMID: 32601072
DOI: 10.1128/JB.00055-20
PMCID: PMC7925083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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