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Article

Downregulation of sFRP-2 by epigenetic silencing activates the β-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma.

Virchows Archiv : an international journal of pathology - 1 Feb 2014

Saito Tsuyoshi, Mitomi Hiroyuki, Imamhasan Abdukadir, Hayashi Takuo, Mitani Keiko, Takahashi Michiko, Kajiyama Yoshiaki, Yao Takashi

Abstract excerpt

Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare variant of typical squamous cell carcinoma (SCC) associated with poor survival. A characteristic feature is nuclear accumulation of β-catenin, without a mutation of the gene. We studied the methylation status of Wnt antagonist genes, such as secreted frizzled-related protein (sFRP) gene family members, Wnt inhibitory factor-1 (WIF-1), Dickkopf-1...

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Share to Carcinoma, Squamous Cell
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Epigenesis, Genetic

Share to Esophageal Neoplasms

Share to Esophageal Squamous Cell Carcinoma

Share to Gene Expression Regulation, Neoplastic

Share to Wnt Signaling Pathway

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PMID: 24464051
DOI: 10.1007/s00428-014-1538-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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