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Article

Aberrant promoter methylation of WIF-1 and SFRP1, 2, 4 genes in mesothelioma

25 Jun 2010

Abstract excerpt

WIF-1 is a negative regulator of the Wnt-signaling pathway that may have important implications for tumorigenesis. Microarray analysis of whole genome expression in mesothelioma tissue revealed down-regulation of 491 genes and up-regulation of 167 genes involved mainly in Jak-STAT signaling (8 genes), MAPK signaling (16 genes) and Wnt signaling (13 genes) pathways. Of these, WIF-1 gene was down-regulated in...

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PMID: 20596629
DOI: 10.3892/or_00000875

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