Article
Deregulation of Wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors.
Carcinogenesis - 1 May 2013
Kim Ji Tae, Li Jing, Jang Eun Ryoung, Gulhati Pat, Rychahou Piotr G, Napier Dana L, Wang Chi, Weiss Heidi L, Lee Eun Y, Anthony Lowell, Townsend Courtney M, Liu Chunming, Evers B Mark
Abstract excerpt
Carcinoid tumors are rare neuroendocrine tumors (NETs) that are increasing in incidence. Mutation and altered expression of Wnt/β-catenin signaling components have been described in many tumors but have not been well-studied in NETs. Here, we observed accumulation of β-catenin in the cytoplasm and/or nucleus in 25% of clinical NET tissues. By mutational analysis, the mutations of β-catenin (I35S) and APC (E1317Q,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.