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Article

Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations.

Oncogene - 21 Apr 2005

He Biao, Reguart Noemi, You Liang, Mazieres Julien, Xu Zhidong, Lee Amie Y, Mikami Iwao, McCormick Frank, Jablons David M

Abstract excerpt

Aberrant Wnt signaling, mainly through mutations of APC and in some cases of CTNNB1 or AXIN2, has been found in the majority of colorectal cancers. Recently, frequent promoter hypermethylation was identified to cause silencing of the secreted frizzled-related protein (sFRP) family in colorectal c...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15735684
DOI: 10.1038/sj.onc.1208511

Genes

APC
AXIN2
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15735684-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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