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Article

Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway.

International journal of cancer - 1 Aug 2010

Su Her-Young, Lai Hung-Cheng, Lin Ya-Wen, Liu Chin-Yun, Chen Chi-Kuan, Chou Yu-Ching, Lin Shin-Ping, Lin Wen-Chi, Lee Hsin-Yi, Yu Mu-Hsien

Abstract excerpt

Oncogenic activation of the Wnt signaling pathway is common in cancers, but mutation of beta-catenin in ovarian cancer is rare. In addition to genetic events, epigenetic modification of secreted frizzled-related protein (SFRP) family has been shown to be important in regulating Wnt signaling. Alt...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19957335
DOI: 10.1002/ijc.25083

Genes

SFRP5
AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19957335-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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