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Article

Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway.

International journal of cancer - 1 Aug 2010

Su Her-Young, Lai Hung-Cheng, Lin Ya-Wen, Liu Chin-Yun, Chen Chi-Kuan, Chou Yu-Ching, Lin Shin-Ping, Lin Wen-Chi, Lee Hsin-Yi, Yu Mu-Hsien

Abstract excerpt

Oncogenic activation of the Wnt signaling pathway is common in cancers, but mutation of beta-catenin in ovarian cancer is rare. In addition to genetic events, epigenetic modification of secreted frizzled-related protein (SFRP) family has been shown to be important in regulating Wnt signaling. Although high degree of homology is observed in the same family, different SFRPs may have opposing effects on the same...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19957335
DOI: 10.1002/ijc.25083

Genes

SFRP5
AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway.PMID 19957335Read ↗

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