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Article

Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.

Journal of gastroenterology - 1 Jan 2008

Takagi Hideyasu, Sasaki Shigeru, Suzuki Hiromu, Toyota Minoru, Maruyama Reo, Nojima Masanori, Yamamoto Hiroyuki, Omata Masao, Tokino Takashi, Imai Kohzoh, Shinomura Yasuhisa

Abstract excerpt

BACKGROUND: Activation of the Wnt signaling pathway is frequently observed in hepatocellular carcinoma (HCC), though mutation of three of its components, CTNNB1, AXIN1, and AXIN2, is observed substantially less often. METHODS: We examined the relationship between Wnt signaling and epigenetic alteration of secreted frizzled-related protein (SFRP) genes in HCC. RESULTS: We frequently detected the active form of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18592156
DOI: 10.1007/s00535-008-2170-0

Genes

SFRP1
SFRP2
SFRP5
SFRP4
AXIN1
AXIN2
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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