Article
Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2007
Suzuki Makoto, Shigematsu Hisayuki, Nakajima Takahiro, Kubo Rieko, Motohashi Shinichiro, Sekine Yasuo, Shibuya Kiyoshi, Iizasa Toshihiko, Hiroshima Kenzo, Nakatani Yukio, Gazdar Adi F, Fujisawa Takehiko
Abstract excerpt
PURPOSE: The Wnt and epidermal growth factor receptor (EGFR) signaling pathways play crucial roles in the pathogenesis of a variety of malignant tumors. Although the details of each cascade are understood, very little is known about their collective effects in non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: A total of 238 NSCLC samples were examined for methylation of Wnt antagonists [secreted...
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