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Article

A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity.

Journal of cell science - 1 Apr 2014

Santos Nicole, Reiter Jeremy F

Abstract excerpt

Signaling through vertebrate Hedgehog (Hh) proteins depends on the primary cilium. In response to Hh signals, the transcriptional activator of the pathway, Gli2, accumulates at the ciliary tip, raising the possibility that ciliary localization is important for Gli2 activation. To test this hypothesis, we used the Floxin system to create knock-in Gli2 alleles in embryonic stem cells (ESCs) to allow methodical...

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Share to Zinc Finger Protein Gli2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24463817
DOI: 10.1242/jcs.139253
PMCID: PMC3970560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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