Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium.

PloS one - 29 Dec 2010

Zeng Huiqing, Jia Jinping, Liu Aimin

Abstract excerpt

Intracellular transduction of Hedgehog (Hh) signals in mammals requires functional primary cilia. The Hh signaling effectors, the Gli family of transcription factors, and their negative regulator, Suppressor of Fused (Sufu), accumulate at the tips of cilia; however, the molecular mechanism regulating this localization remains elusive. In the current study, we show that the ciliary localization of mammalian Gli...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cilia
Share to Cyclic AMP-Dependent Protein Kinases
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Protein Transport

Share to Zinc Finger Protein GLI1

Share to Zinc Finger Protein Gli2

Share to Zinc Finger Protein Gli3

Source

Open in PubMed Open full text

Identifiers

PMID: 21209912
DOI: 10.1371/journal.pone.0015900
PMCID: PMC3012114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium.PMID 21209912Read ↗

A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity.Semantic proximity Read ↗

PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant.Semantic proximity Read ↗

The primary cilium as a Hedgehog signal transduction machine.Semantic proximity Read ↗

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.Semantic proximity Read ↗

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Semantic proximity Read ↗

Cilia-dependent GLI processing in neural crest cells is required for tongue development.Semantic proximity Read ↗

Gli proteins encode context-dependent positive and negative functions: implications for development and diseaseSemantic proximity Read ↗

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling.Semantic proximity Read ↗

Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and FunctionSemantic proximity Read ↗

GliFHV mice: a tool to investigate GLI processing and localization.Semantic proximity Read ↗

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.Semantic proximity Read ↗

Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.