Article

<i>Zfp423</i> regulates Sonic hedgehog signaling via primary cilium function

2016-04-05

Abstract excerpt

Zfp423 encodes a 30-zinc finger transcription factor that intersects several canonical signaling pathways. Zfp423 mutations result in ciliopathy-related phenotypes, including agenesis of the cerebellar vermis in mice and Joubert syndrome (JBTS19) and nephronophthisis (NPHP14) in humans. Unlike most ciliopathy genes, Zfp423 encodes a nuclear protein and its developmental expression is complex, leading to alternat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 04cc0fc0-b9e2-5fd9-976a-f34f77b0fc91
DOI: 10.1101/046961

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Zfp423</i> regulates Sonic hedgehog signaling via primary cilium functionDOI 10.1101/046961Read

Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.Semantic proximity Read

<i>Zfp423</i> , a Joubert syndrome gene, is a domain-specific regulator of cell cycle progression, DNA damage response and Purkinje cell development in the cerebellar primordiumSemantic proximity Read

ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexusSemantic proximity Read

Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation.Semantic proximity Read

Dual and Opposing Roles for the Kinesin-2 Motor, KIF17, in Hedgehog-dependent Cerebellar DevelopmentSemantic proximity Read

<i>Tulp3</i> quantitative alleles titrate requirements for viability, brain development, and kidney homeostasis but do not suppress <i>Zfp423</i> mutations in miceSemantic proximity Read

Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors.Semantic proximity Read

Perdurant TTC21B protein in the early mouse embryo is required for proper forebrain neural progenitor proliferationSemantic proximity Read

Unmasking the ciliopathies: craniofacial defects and the primary cilium.Semantic proximity Read

Primary Cilia in Brain Development and Diseases.Semantic proximity Read

Mice with a conditional deletion of Talpid3 (KIAA0586) – a model for Joubert syndromeSemantic proximity Read

Zfp423 is required for normal cerebellar development.Semantic proximity Read