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Article

Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.

PLoS genetics - 1 Oct 2016

Hong Chen-Jei, Hamilton Bruce A

Abstract excerpt

Zfp423 encodes a 30-zinc finger transcription factor that intersects several canonical signaling pathways. Zfp423 mutations result in ciliopathy-related phenotypes, including agenesis of the cerebellar vermis in mice and Joubert syndrome (JBTS19) and nephronophthisis (NPHP14) in humans. Unlike most ciliopathy genes, Zfp423 encodes a nuclear protein and its developmental expression is complex, leading to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27727273
DOI: 10.1371/journal.pgen.1006357
PMCID: PMC5065120

Genes

IFT88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.PMID 27727273Read ↗

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