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Article

GliFHV mice: a tool to investigate GLI processing and localization.

Development (Cambridge, England) - 1 Nov 2025

Dear Hannah Schrader, Franks Nicole E, Markley Ella E, Holtz Alexander M, Song Jane Y, Johnson Craig N, Medina-Cabrera Paola I, Hernandez Daniela, Joel Praise, Pasca di Magliano Marina, Wellik Deneen M, Allen Benjamin L

Abstract excerpt

GLI proteins (GLI1-3) are the transcriptional effectors of mammalian hedgehog (HH) signaling. However, studies of GLI function have been hampered by the lack of robust GLI antibodies. To address this, we utilized CRISPR-based gene editing to generate endogenous epitope-tagged Gli alleles for each Gli gene (Gli1FLAG, Gli2HA, Gli3V5). Through breeding, we established a novel mouse model,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 41058551
DOI: 10.1242/dev.204251
PMCID: PMC12614490

Genes

GLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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