Article
Folding a stable RNA pseudoknot through rearrangement of two hairpin structures.
Nucleic acids research - 1 Apr 2014
Wu Yi-Ju, Wu Cheng-Han, Yeh Athena Yi-Chun, Wen Jin-Der
Abstract excerpt
Folding messenger RNA into specific structures is a common regulatory mechanism involved in translation. In Escherichia coli, the operator of the rpsO gene transcript folds into a pseudoknot or double-hairpin conformation. S15, the gene product, binds only to the pseudoknot, thereby repressing its own synthesis when it is present in excess in the cell. The two RNA conformations have been proposed to exist in...
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