Article
Molecular dissection of the pseudoknot governing the translational regulation of Escherichia coli ribosomal protein S15.
Nucleic acids research - 11 Jan 1995
Philippe C, Bénard L, Portier C, Westhof E, Ehresmann B, Ehresmann C
Abstract excerpt
The ribosomal protein S15 controls its own translation by binding to a mRNA region overlapping the ribosome binding site. That region of the mRNA can fold in two mutually exclusive conformations that are in dynamic equilibrium: a structure with two hairpins and a pseudoknot. A mutational analysis provided evidence for the existence and requirement of the pseudoknot for translational control in vivo and S15...
Topics
- Base Sequence
- Binding Sites
- Escherichia coli
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Biosynthesis
- Protein Conformation
- RNA, Bacterial
- RNA, Messenger
- Ribosomal Proteins