Article
RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus.
Nucleic acids research - 1 Feb 2013
Ishimaru Daniella, Plant Ewan P, Sims Amy C, Yount Boyd L, Roth Braden M, Eldho Nadukkudy V, Pérez-Alvarado Gabriela C, Armbruster David W, Baric Ralph S, Dinman Jonathan D, Taylor Deborah R, Hennig Mirko
Abstract excerpt
Messenger RNA encoded signals that are involved in programmed -1 ribosomal frameshifting (-1 PRF) are typically two-stemmed hairpin (H)-type pseudoknots (pks). We previously described an unusual three-stemmed pseudoknot from the severe acute respiratory syndrome (SARS) coronavirus (CoV) that stimulated -1 PRF. The conserved existence of a third stem-loop suggested an important hitherto unknown function. Here we...
Topics
- Base Sequence
- Codon
- Conserved Sequence
- Dimerization
- Frameshifting, Ribosomal
- Inverted Repeat Sequences
- Kinetics
- Magnesium
- Microbial Viability
- Molecular Sequence Data
- Mutation
- Nuclear Magnetic Resonance, Biomolecular