Article
Genetic analysis of the structure and function of transfer messenger RNA pseudoknot 1.
The Journal of biological chemistry - 14 Apr 2006
Tanner Douglas R, Dewey Jonathan D, Miller Mickey R, Buskirk Allen R
Abstract excerpt
tmRNA rescues stalled ribosomes in eubacteria by forcing the ribosome to abandon its mRNA template and resume translation with tmRNA itself as a template. Pseudoknot 1 (pk1), immediately upstream of this coding region in tmRNA, is a structural element that is considered essential for tmRNA function based on the analysis of pk1 mutants in vitro. pk1 binds near the ribosomal decoding site and may make base-specific...
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