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Dietary lipids attenuate IGF-1-Akt and injure epithelial-endothelial injury program that accelerates obstructive lung disease

2026-02-01

Abstract excerpt

<h4>SUMMARY</h4> Metabolic lipotoxicity injures multiple organs, but its impact on the lung remains unclear. Here we show that a high-fat diet (HFD) accelerates obstructive pathology in βENaC-transgenic mice and worsens elastase-induced emphysema. Lung transcriptomics reveal repression and rewiring of PI3K–Akt survival circuitry; in both models, phospho-Akt is reduced, FOXO1 is increased, and epithelial apoptosis...

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Literature Corpus work
a9489403-0db7-5d06-b1d2-59d4e78208d4
DOI
10.64898/2026.01.29.702619
Open publication

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Dietary lipids attenuate IGF-1-Akt and injure epithelial-endothelial injury program that accelerates obstructive lung diseaseDOI 10.64898/2026.01.29.702619
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